The name Comet comes about since the samples look like a comet having a head and a tail extending to different lengths relative to the amount of DNA integrity or damage. Types of DNA damage that occur include single-/double-strand breaks, DNA-drug crosslinking, DNA-protein or DNA-DNA crosslinking and oxidative DNA base damage. No, it’s not a technique in astronomy whereby the solar system and beyond is scanned to assess the risk of the human race following the fate of the dinosaurs! For those that do "Single Cell Gel (SCG) electrophoresis", Comet is a highly sensitive and efficient means of assessing and quantifying DNA damage and repair at the level of the individual cell, and is applicable to any eukaryotic cell. Comet assay:Quantifying DNA damage and repair at single cell levelĬomet image courtesy of Marie Vasquez, Helex 3 Inc.
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